Nanjing Biocell Environmental Technology Co., Ltd.
Nanjing Biocell Environmental Technology Co., Ltd.

Biocell WFI water for injection system adopts an advanced three-stage separation WFI generation process of steam and water, and the quality of produced water meets the standards of Chinese, American, and European Pharmacopoeia, GMP, FDA, and other certification requirements; our wfi generation system has humanized design, modular installation, small floor area, stable operation, one button start, simple operation and maintenance, high efficiency, and energy saving. 

Different Types of WFI Generation Systems

Multi-Effect Distiller Multi-Effect Distiller
The multi effect distilled water machine is designed and manufactured according to the industry standard YY0229 Multi effect Distilled Water Machine. All parts are made of 304 and 316L stainless steel. The distilled water produced is of high purity and pyrogen free, and fully complies with the quality indicators of water for injection in the Pharmacopoeia of the People's Republic of China (2020). It is the ideal equipment for manufacturers of various blood products, injections, infusion, biological antibacterial and other drugs and manufacturers of drinking distilled water.
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Single Effect Distiller Single Effect Distiller
The single effect distilled water machine is a small distillation unit designed to meet the needs and budgets of growing organizations interested in developing new products. Up to 300L of water for injection can be produced per hour.
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Electrically Heated Distiller Electrically Heated Distiller
The electric heating distilled water machine uses purified water as raw water and electric energy (converted into heat energy) as heating source, and the distilled water produced completely meets the quality indicators of "water for injection" in the Chinese Pharmacopoeia 2020.
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Combis TWO in ONE Combis TWO in ONE
This model is applicable to the production conditions of producing pure steam disinfection on one side and water for injection on the other side. Disinfection and water preparation can operate simultaneously and independently without mutual interference. It is a production equipment that can operate in dual synchronization, and water production and steam production do not affect each other.
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WFI Cold Generation System WFI Cold Generation System
The production capacity of cold water for injection (full membrane method) is 200-30000L/H, which is used in medical, daily chemical and other industries. It uses terminal ultrafiltration technology to remove heat source impurities on the basis of traditional purified water, so that the endotoxin index is lower than the standard requirements of "water for injection" in the pharmacopoeia, providing a new, stable and reliable choice for related enterprises to prepare water for injection.
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What Is the WFI Generation System Working Principle?

The WFI system in pharmaceutical industry has low investment cost, low operation, and energy consumption, and can operate continuously and dynamically. Under the condition of low-temperature storage and turbulence, water for injection machine can effectively control the microbial breeding risk of the whole system and can realize large-scale water supply.


wfi storage and distribution system

What Is the WFI Generation System Working Principle?

What Is Water for Injection (WFI)?

Water for injection (WFI) is a high-purity water used in the pharmaceutical industry for the preparation of injectable medications and medical devices. WFI system must meet strict quality standards to ensure that it is free from microbial and chemical contaminants that could harm patients.



What Is WFI Generator Used For

The water for injection (WFI) system is used as a diluent or solvent for drugs that are administered by injection, including intravenous, intramuscular, and subcutaneous injections. Water for injection system is also used as a component in the preparation of medical devices, such as wound dressings and contact lenses.

The high purity of WFI is critical to ensure the safety and efficacy of the medications and devices prepared with it. Even trace amounts of contaminants can cause adverse reactions in patients, such as infections or allergic reactions. Therefore, water for injection systems is subject to strict quality standards and is regularly tested to ensure that it meets the required specifications.



WFI System Generation Process

The generation of water for injection (WFI) system in the water system pharmaceutical industry typically involves a multi-step process to remove impurities and contaminants from the feed water. The WFI generation process may include the following steps:


Pretreatment: The first step is to remove large particles and suspended solids from the feed water. This may be accomplished by using filters, such as sand or cartridge filters.


Reverse osmosis (RO): The pretreated water is then passed through a reverse osmosis membrane, which removes dissolved salts and other impurities. RO uses high pressure to force water through a semi-permeable membrane that separates the water from dissolved salts and other contaminants.


Electrodeionization (EDI): The RO permeate is then passed through an electrodeionization (EDI) module, which uses a combination of ion exchange and electrochemical processes to remove the remaining ions from the water.


Distillation: In some cases, WFI is generated by distilled water. This involves heating the feed water to generate steam, which is then condensed to produce high-purity water.


Ultrafiltration: Ultrafiltration is a process that can be used in combination with the other steps to remove endotoxins and other small particles from the water.

What Is Water for Injection (WFI)?

Water for Injection System Solutions

  • wfi water system
    First
    WFI By Distillation

    At present, water for injection system (WFI) is mainly obtained by the following thermal distillation methods:

    Single-effect or multi-effect thermal distillation is the most popular production method of water for injection (WFI) machine. The main advantages of this method are a simple design, and no moving parts used in the WFI water generation process, so it has reliability. Since the process of water for injection machine is carried out at high temperatures, the method has full confidence in the microbial purity of the water obtained.

  • water for injection system
    Second
    Cold WFI by Membrane Methods

    When using the whole membrane method to prepare cold water for injection, special attention should be paid to the design of regular sanitary treatment of the system. Cold process is always more susceptible to microbial contamination than traditional hot distillation. The cold WFI power generation equipment shall be cleaned regularly, preferably by thermal disinfection.

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